As of 9:15 a.m., the 225-issue Nikkei Stock Average lost 48.39 points, or 0.23 percent, from Tuesday to 21,018.84. The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, shed 0.79 point, or 0.05 percent, at 1,534.19.
Pharmaceutical, iron and steel, and transportation equipment-linked issues comprised those that declined the most in the opening minutes after the morning bell.
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