The 225-issue Nikkei Stock Average dropped 176.04 points, or 0.78 percent, from Tuesday to close the day at 22,438.65.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 14.48 points, or 0.92 percent, to finish at 1,557.23.
Mining, insurance and bank-oriented issues comprised those that declined the most by the close of play.
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