As of 9:15 a.m., the 225-issue Nikkei Stock Average shed 21.12 points, or 0.09 percent, from Thursday to 23,486.11.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 7.24 points, or 0.44 percent, at 1,624.55.
Real estate and pharmaceutical issues led notable decliners, while marine transportation and insurance issues led those that gained the most in the opening minutes after the morning bell.
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