The spacecraft undocked at 12:30 p.m. Eastern Time Thursday from the space-facing port of the station's Harmony module.
After re-entering Earth's atmosphere, the spacecraft will make a parachute-assisted splashdown off the coast of the southeastern U.S. state of Florida on Friday, according to NASA.
Dragon will carry back to Earth over 3,600 pounds of supplies and scientific experiments designed to take advantage of the space station's microgravity environment, according to NASA.
The spacecraft was launched June 5 on a SpaceX Falcon 9 rocket from NASA's Kennedy Space Center, and arrived at the ISS on June 6, delivering more than 7,000 pounds of research investigations, crew supplies, and station hardware.
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