The Dow Jones Industrial Average fell 100.69 points, or 0.40 percent, to 25,286.49. The S&P 500 sank 4.04 points, or 0.15 percent, to 2,722.18. The Nasdaq Composite Index increased 0.01 points, or 0.0001 percent, to 7,200.88.
Shares of Exxon Mobil and Boeing slid 2.29 percent and 2.11 percent, respectively, leading the laggards in the Dow.
Six of the 11 primary S&P 500 sectors traded lower, with energy down 2.39 percent, the biggest loser among the sectors.
The tech sector closed 0.09 percent higher, giving up some of the handsome gains in early trading.
Tuesday's market was quite volatile, with all the three major indices swinging frequently between positive and negative territories.
"The buyers and sellers are fighting each other every day. When we see major trade agreements being reformed and a new consensus on interest rates, as well as currency uncertainty, it causes this type of action," John Monaco, trader at Wellington Shields & Co. LLC, told Xinhua.
On the economic front, U.S. small business optimism index declined to 107.4 in October from 107.9 in September, according to a report released by the National Federation of Independent Business on Tuesday. The reading also marked a four-month low.