Chinese stocks opened lower on Wednesday, with the benchmark Shanghai Composite Index down 1.36 percent to open at 2,629.83 points.
The Shenzhen Component Index opened 1.62 percent lower at 7,825.12 points.
The ChiNext Index, China's NASDAQ-style board of growth enterprises, was down 1.41 percent to open at 1,359.27 points.
Hong Kong stocks lost 514.75 points, or 1.89 percent, to open at 26,745.69 points on Wednesday.
Tokyo stocks opened lower Wednesday, following an overnight equities rout on Wall Street over concerns for the outlook of the U.S. economy.
In the opening minutes of trading, the 225-issue Nikkei Stock Average dropped 164.56 points, or 0.75 percent, from Tuesday to 21,871.49.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 14.59 points, or 0.88 percent, at 1,634.61.
Insurance, oil and coal product, and marine transportation-linked issues comprised those that declined the most in the opening minutes after the morning bell.