The Dow Jones Industrial Average was down 79.29 points, or 0.30 percent, to 26,179.13. The S&P 500 was up 0.05 points, or 0.0017 percent, to 2,867.24. The Nasdaq Composite Index rose 19.78 points, or 0.25 percent, to 7,848.69.
Shares of Walgreens Boots Alliance plunged 12.8 percent at the close, leading the decliners in the 30-stock index.
The Dow component on Tuesday reported its fiscal second-quarter earnings that missed Wall Street estimates.
The firm also slashed its full-year earnings guidance for 2019.
The S&P 500 closed roughly flat, as the solid gains in real estate, communication services and materials mainly offset the losses in consumer staples and energy.
Shares of Facebook rallied more than 3 percent, contributing to the Nasdaq.
On the economic front, new orders for U.S. manufactured durable goods decreased 1.6 percent in February after three consecutive monthly increases, the Commerce Department said on Tuesday.
Meanwhile, shipments of manufactured durable goods increased 0.2 percent in February, following a 0.4 percent January decrease.