The Dow Jones Industrial Average was down 11.40 points, or 0.04 percent, to 26,536.82. The S&P 500 lost 3.60 points, or 0.12 percent, to 2,913.78.
The Nasdaq Composite Index rose 25.25 points, or 0.32 percent, to 7,909.97. New orders for manufactured durable goods in May decreased 3.3 billion U.S. dollars, or 1.3 percent, to 243.4 billion dollars, the Commerce Department said on Wednesday.
The decline, the third time in four months, was largely due to a canceled deal for Boeing's 737 Max jet.
A separate report on international trade in goods showed that the U.S. trade deficit climbed 5.1 percent in May to reach 74.5 billion dollars.
On Tuesday, all three major indexes declined as the market was disappointed after Federal Reserve Chairman Jerome Powell's remarks on the central bank's possible monetary policy moves dampened hopes for a rate cut soon, as well as weaker-than-expected economic data.