The Dow Jones Industrial Average fell 109.33 points, or 0.45 percent, to 24,221.99. The S&P 500 rose 0.39 points, or 0.01 percent, to 2,930.19. The Nasdaq Composite Index increased 71.02 points, or 0.78 percent, to 9,192.34.
Seven of the 11 primary S&P 500 sectors ended lower, with financials and energy down 1.94 percent and 1.69 percent, respectively, leading the laggards. Health care and technology were up 1.67 percent and 0.7 percent, respectively, leading the gainers.
The mixed finish came as a growing number of U.S. states started to ease restrictions on business.
"Investors will be keen to see whether economies can sustainably reopen without the threat of a significant second wave of new coronavirus cases, especially since multiple economies, which have already begun reopening, have reported setbacks," UBS Global Wealth Management's Chief Investment Officer Mark Haefele said in a note.
As of Monday afternoon, more than 1.34 million confirmed COVID-19 cases have been reported in the United States, with over 80,000 deaths, according to the Center for Systems Science and Engineering at Johns Hopkins University.
For the week ending May 8, the Dow advanced 2.6 percent, the S&P 500 gained 3.5 percent, and the Nasdaq climbed 6 percent.
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