Shares of ZTO Express and Yum China Holdings slipped 5.34 percent and 3.96 percent, respectively, leading the laggards in the top 10 stocks in the index.
Shares of NetEase and Baidu climbed 2.93 percent and 1.39 percent, respectively, leading the advancers in the top 10 stocks.
U.S. stocks ended lower on Thursday as investors digested a slew of newly-released economic data.
The Dow Jones Industrial Average fell 101.78 points, or 0.41 percent, to 24,474.12. The S&P 500 was down 23.10 points, or 0.78 percent, to 2,948.51. The Nasdaq Composite Index decreased 90.90 points, or 0.97 percent, to 9,284.88.
The Cboe Volatility Index, widely considered as the best fear gauge in the stock market, rose 5.5 percent to 29.53.
As of Wednesday, the S&P U.S. Listed China 50 index stood at 3,534.85, marking a 9.33-percent increase for the month-to-date returns and an 11.61-percent gain for the year-to-date returns.