The Dow Jones Industrial Average rose 10.50 points, or 0.04 percent, to 26,085.80. The S&P 500 dropped 29.82 points, or 0.94 percent, to 3,155.22. The Nasdaq Composite Index shed 226.60 points, or 2.13 percent, to 10,390.84.
All the three indexes rallied earlier in the day with the 30-stock average jumping as much as 563.79 points.
U.S.-listed Chinese companies traded mostly lower, with eight of the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on a downbeat note.
Investors remained cautious as new COVID-19 infections continued to surge in the United States.
More than 3.34 million confirmed COVID-19 cases have been reported in the United States, with over 135,000 deaths, as of Monday afternoon, showed a tally by Johns Hopkins University.
Wall Street also paid close attention to corporate earnings.
PepsiCo reported better-than-expected second-quarter earnings on Monday. The stock closed 0.33 percent higher.
Results from major financial institutions will dominate the week, with banks including JPMorgan Chase, Citigroup, Morgan Stanley and Goldman Sachs each set to deliver earnings results.
The estimated earnings decline for the S&P 500 is 43.8 percent for the second quarter, according to data from FactSet as of early July.
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