Shares of NIO and Bilibili dropped 6.04 percent and 5.86 percent, respectively, leading the losses in the top 10 stocks in the index.
Shares of NetEase and Pinduoduo slipped 5.17 percent and 2.8 percent, respectively, also among the worst performers in the top 10 stocks.
U.S. stocks finished lower on Wednesday as investors remained cautious amid a continued rise in COVID-19 infections.
The Dow Jones Industrial Average decreased 68.93 points, or 0.20 percent, to 35,031.07. The S&P 500 fell 5.96 points, or 0.13 percent, to 4,514.07. The Nasdaq Composite Index was down 87.69 points, or 0.57 percent, to 15,286.64.
The Cboe Volatility Index, widely considered as the best fear gauge in the stock market, dipped 0.99 percent at 17.96.
As of Tuesday, the S&P U.S. Listed China 50 index, which is designed to track the performance of the 50 largest Chinese companies listed on U.S. exchanges by total market cap, stood at 3,959.01, marking a 5.39-percent gain for the month-to-date returns and a 24.22-percent slide for the year-to-date returns.
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