The Shenzhen Component Index closed 2.2 percent lower at 13,252.24 points.
The combined turnover of stocks covered by the two indices came in at 1.36 trillion yuan (215.28 billion U.S. dollars), up from 1.04 trillion yuan on the previous trading day.
Stocks related to oil and gas mining and precious metals led the gains, while those related to digital currency led the losses.
The ChiNext Index, tracking China's NASDAQ-style board of growth enterprises, lost 2.11 percent to close at 2,783.9 points.
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