The Shenzhen Component Index closed 1.37 percent lower at 13,020.46 points.
The combined turnover of stocks covered by the two indices came in approximately at 1.01 trillion yuan (159.6 billion U.S. dollars), basically unchanged from the previous trading day.
Stocks related to medicine and cloud games led the gains, while those related to oil and gas exploitation posted lackluster performances.
The ChiNext Index, tracking China's NASDAQ-style board of growth enterprises, lost 1.55 percent to close at 2,748.64 points Friday.
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