The Shenzhen Component Index closed 0.83 percent lower at 12,305.5 points.
The combined turnover of stocks covered by the two indices came in at about 920 billion yuan (145 billion U.S. dollars), down from 943 billion yuan on the previous trading day.
Shares related to pharmaceutical business posted stellar performance, while shares related to digital currency and electronic ID saw heavy losses.
The ChiNext Index, tracking China's Nasdaq-style board of growth enterprises, lost 0.36 percent to close at 2,706.21 points.
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