Shares of Bilibili and BeiGene dropped 9.36 percent and 8.45 percent, respectively, leading the losses in the top 10 stocks in the index.
Shares of Pinduoduo and Baidu slid 8.34 percent and 8.02 percent, respectively, also among the worst performers in the top 10 stocks.
U.S. stocks dropped on Thursday with financial sector leading the losses.
The Dow Jones Industrial Average decreased 550.46 points, or 1.56 percent, to 34,678.35. The S&P 500 fell 72.04 points, or 1.57 percent, to 4,530.41. The Nasdaq Composite Index was down 221.75 points, or 1.54 percent, to 14,220.52.
The Cboe Volatility Index, widely considered as the best fear gauge in the stock market, rose 6.36 percent to 20.56.
As of Wednesday, the S&P U.S. Listed China 50 index, which is designed to track the performance of the 50 largest Chinese companies listed on U.S. exchanges by total market cap, stood at 2,490.82, marking a 7.37-percent slide for the month-to-date returns and a 16.37-percent loss for the year-to-date returns.
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