The Dow Jones Industrial Average fell 148.47 points, or 0.49 percent, to 30,069.79. The S&P 500 dipped 7.16 points, or 0.19 percent, to 3,691.96. The Nasdaq Composite Index was up 55.71 points, or 0.45 percent, to 12,519.95.
Eight of the 11 primary S&P 500 sectors pulled back, with energy closing down 2.44 percent, leading the laggards. Communications services rose 0.61 percent, the best-performing group.
U.S.-listed Chinese companies traded roughly flat, with five of the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on an upbeat note.
The market reactions came as the upward trajectory of new coronavirus cases in the United States continued.
The United States has reported a record-high average of more than 196,200 daily cases over the past seven days, up over 20 percent compared with a week ago, according to a CNBC analysis of data compiled by Johns Hopkins University. The country has registered more than 14.88 million confirmed cases in total with the death toll exceeding 283,000 as of Monday afternoon.
For the week ending Friday, the Dow and the S&P 500 climbed 1 percent and 1.7 percent, respectively, while the Nasdaq gained 2.1 percent.
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