At 10:30 (AEST), the benchmark ASX 200 index was up 11.60 points or 0.17 percent at 6,784.60, while the broader All Ordinaries index was up 15.20 points or 0.22 percent at 7,034.30.
European share markets sagged as more countries suspended distribution of AstraZenenca's COVID vaccine on reports of adverse reactions.
However, U.S. share markets were unfazed, with the S&P 500 and Dow Jones closing at record highs and the Nasdaq bouncing back with a 1.10 percent gain.
"Asia Pacific futures markets indicate the region will follow positive U.S. leads rather than heed the vaccine concerns," CMC Markets chief market strategist Michael McCarthy said.
"Global markets appeared to take the view that this is a problem specific to Europe, as base metals rallied and currency markets traded calmly."
On the local bourse, information technology and real estate were leading gains, up 1.34 percent and 1.09 percent respectively.
In the financial space, the big banks were mixed with Commonwealth Bank up (0.32 percent), National Australia Bank down (0.61 percent), Westpac Bank down (0.20 percent) and ANZ down (0.42 percent).
Mining stocks varied with BHP down (1.59 percent), Rio Tinto down (0.37 percent), Fortescue Metals up (0.20 percent), and gold miner Newcrest up (1.36 percent).
The country's oil and gas producers slumped with Oil Search down (1.13 percent), Santos down (0.95 percent) and Woodside Petroleum down (1.32 percent).
Australia's largest supermarkets lifted with Coles up (0.48 percent), and Woolworths up (0.41 percent).
Meanwhile, telecommunications giant Telstra sank (0.65 percent), the national carrier Qantas slipped (0.36 percent) and biomedical firm CSL strengthened (0.70 percent).
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