The Dow Jones Industrial Average increased 45.86 points, or 0.13 percent, to 34,575.31. The S&P 500 fell 2.07 points, or 0.05 percent, to 4,202.04. The Nasdaq Composite Index decreased 12.26 points, or 0.09 percent, to 13,736.48.
Six of the 11 primary S&P 500 sectors ended in green, with energy up 3.93 percent, leading the gainers. Health care slipped 1.64 percent, the worst-performing group.
U.S.-listed Chinese companies traded higher with all the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on an upbeat note.
On the economic front, the U.S. manufacturing PMI (Purchasing Managers' Index) rose to 61.2 percent in May from 60.7 percent in April, the Institute for Supply Management (ISM) reported on Tuesday. Economists surveyed by Dow Jones and The Wall Street Journal had forecast the ISM index to edge up to 60.7 percent. Readings over 50 percent signal expansion.
U.S. financial markets were closed on Monday in observance of the Memorial Day holiday.
Last week, Wall Street's major averages eked out modest gains with the Dow and the S&P 500 up 0.9 percent and 1.2 percent, respectively, while the tech-heavy Nasdaq notching a weekly rise of 2.1 percent.
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