The Dow Jones Industrial Average fell 269.09 points, or 0.76 percent, to 35,100.00. The S&P 500 decreased 15.40 points, or 0.34 percent, to 4,520.03. The Nasdaq Composite Index increased 10.81 points, or 0.07 percent, to 15,374.33.
Eight of the 11 primary S&P 500 sectors ended in red, with industrials down 1.77 percent, leading the laggards. Communication services rose 0.45 percent, the best-performing group.
U.S.-listed Chinese companies traded mostly higher with nine of the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on an upbeat note.
Investors were assessing the impact of a resurgence in COVID-19 infections as the pandemic continues in the United States, with the Delta variant in a sustained uptrend and hospitalizations on the rise.
The total number of COVID-19 cases in the United States topped 40 million on Monday, according to data from Johns Hopkins University.
The average daily increase of cases in the country was 127,100 in the seven-day period ending Monday, showed the latest data compiled by the U.S. Centers for Disease Control and Prevention.
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