The Dow Jones Industrial Average was up 90.42 points, or 0.25 percent, to 36,488.63, posting its sixth-straight winning day. The S&P 500 rose 6.71 points, or 0.14 percent, to 4,793.06. The Nasdaq Composite Index lost 15.51 points, or 0.10 percent, to 15,766.22.
Eight of the 11 primary S&P 500 sectors ended in green, with real estate and health care up 0.64 percent and 0.6 percent, respectively, outpacing the rest. Energy slipped 0.63 percent, the worst-performing group.
U.S.-listed Chinese companies traded lower with all the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on a downbeat note.
The above market reactions came as the COVID-19 infections continue to spike in the United States, fueled by soaring cases of the Omicron variant.
The country's 7-day average daily increase of cases reached more than 277,000, a 215-percent spike from a month ago, according to latest data from the U.S. Centers for Disease Control and Prevention.
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