The Dow Jones Industrial Average fell 211.16 points, or 0.63 percent, to 33,536.70. The S&P 500 slipped 35.68 points, or 0.89 percent, to 3,957.25. The Nasdaq Composite Index decreased 127.11 points, or 1.12 percent, to 11,196.22.
Ten of the 11 primary S&P 500 sectors ended in red, with real estate and consumer discretionary down 2.65 percent and 1.71 percent, respectively, leading the laggards. Health care rose 0.03 percent, the lone gaining group.
The above market reactions came as investors reassessed the Federal Reserve's future policy path.
Fed Governor Christopher Waller said Sunday that the central bank still had "a ways to go" before ending rate hikes.
Last week, Wall Street reaped solid gains as a smaller-than-expected increase in U.S. inflation rekindled hopes of a dovish pivot from the Fed.
For the week ending Friday, the Dow rose 4.1 percent, the S&P 500 gained 5.9 percent and the Nasdaq jumped 8.1 percent. It marked the best week since June for the S&P 500, and the Nasdaq's best weekly performance since March.
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