The 225-issue Nikkei Stock Average lost 126.45 points, or 0.56 percent, from Tuesday to close the day at 22,455.76.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 6.36 points, or 0.40 percent, to finish at 1,587.09.
Air transportation, land transportation and textile and apparel-linked issues comprised those that declined the most by the close of play.
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