Shares of Bilibili and BeiGene slid 6.42 percent and 5.6 percent, respectively, leading the laggards in the top 10 stocks in the index.
Shares of Yum China Holdings and JD.com climbed 1.72 percent and 1.66 percent, respectively, the only two gainers in the top 10 stocks.
U.S. stocks fell in volatile trading on Monday as investors bet on aggressive policy tightening from the Federal Reserve in the coming months amid high inflation.
The Dow Jones Industrial Average fell 39.54 points, or 0.11 percent, to 34,411.69. The S&P 500 lost 0.90 points, or 0.02 percent, to 4,391.69. The Nasdaq Composite Index decreased 18.72 points, or 0.14 percent, to 13,332.36.
The Cboe Volatility Index, widely considered as the best fear gauge in the stock market, dipped 2.33 percent to 22.17.
U.S. equities markets were closed on Friday in observance of Good Friday.
As of Thursday, the S&P U.S. Listed China 50 index, which is designed to track the performance of the 50 largest Chinese companies listed on U.S. exchanges by total market cap, stood at 2,314.52, marking a 1.44-percent slide for the month-to-date returns and a 22.29-percent loss for the year-to-date returns.
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