The Dow Jones Industrial Average fell 39.54 points, or 0.11 percent, to 34,411.69. The S&P 500 lost 0.90 points, or 0.02 percent, to 4,391.69. The Nasdaq Composite Index decreased 18.72 points, or 0.14 percent, to 13,332.36.
Six of the 11 primary S&P 500 sectors ended in red, with health care down 1.12 percent, leading the laggards. Energy rose 1.51 percent, the best-performing group.
U.S.-listed Chinese companies traded mostly lower, with eight of the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on a downbeat note.
The above market reactions came as concerns over high U.S. inflation and a hawkish Fed remain a focus on Wall Street.
U.S. equities markets were closed on Friday in observance of Good Friday. For the holiday-shortened trading week ending Thursday, the Dow and S&P 500 slipped 0.8 percent and 2.1 percent, respectively, while tech-heavy Nasdaq shed 2.6 percent.
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