The 225-issue Nikkei Stock Average dropped 353.98 points, or 1.50 percent, from Tuesday to close the day at 23,185.12.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, fell 32.61 points, or 1.97 percent, to finish at 1,625.49.
Bank, securities house and air transportation-linked issues comprised those that declined the most by the close of play.
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