The Dow Jones Industrial Average fell 61.92 points, or 0.18 percent, to 33,981.57. The S&P 500 rose 7.45 points, or 0.18 percent, to 4,187.62. The Nasdaq Composite Index advanced 121.97 points, or 0.87 percent, to 14,138.78.
Seven of the 11 primary S&P 500 sectors ended in green, with energy up 0.64 percent, leading the gainers. Consumer staples slipped 1.16 percent, the worst-performing group.
U.S.-listed Chinese companies traded mostly higher with seven of the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on an upbeat note.
Wall Street is bracing for a busy week of the first-quarter earnings season. About a third of the S&P 500 companies are set to report this week, including earnings results from big tech names such as Apple, Amazon, Microsoft and Google-parent Alphabet.
Investors will also look to a key meeting of the U.S. Federal Reserve. The U.S. central bank will kick off its two-day policy meeting on Tuesday, with a monetary policy decision and press conference from Federal Reserve Chair Jerome Powell slated for Wednesday afternoon.
For the week ending Friday, the Dow fell 0.5 percent, the S&P 500 declined 0.1 percent, and the Nasdaq lost 0.3 percent.