The Dow Jones Industrial Average decreased 68.93 points, or 0.20 percent, to 35,031.07. The S&P 500 fell 5.96 points, or 0.13 percent, to 4,514.07. The Nasdaq Composite Index was down 87.69 points, or 0.57 percent, to 15,286.64.
Six of the 11 primary S&P 500 sectors ended in red, with energy down 1.3 percent, leading the laggards. Utilities rose 1.79 percent, the best-performing group.
U.S.-listed Chinese companies traded lower with all the top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on a downbeat note.
Investors worried that a rapid spread of the Delta variant of COVID-19 would impact economic recovery.
More than 40.3 million COVID-19 cases have been reported in the United States, with over 651,800 related fatalities as of Wednesday afternoon, according to data from Johns Hopkins University.
The average daily increase of cases in the country was over 140,000 in the seven-day period ending Tuesday, showed the latest statistics compiled by the U.S. Centers for Disease Control and Prevention.
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