As of 9:15 a.m., the 225-issue Nikkei Stock Average shed 17.57 points, or 0.08 percent, from Thursday to 21,625.96. The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 0.69 point, or 0.04 percent, at 1,577.94.
Mining and pharmaceutical issues led notable decliners, while insurance and precision instrument-linked issues comprised those that gained the most in the opening minutes after the morning bell.
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