As of 9:15 a.m., the 225-issue Nikkei Stock Average dropped 206.36 points, or 0.96 percent, from Tuesday to 21,381.42.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 12.68 points, or 0.80 percent, at 1,573.82.
Mining, precision instrument and marine transportation-linked issues comprised those that declined the most in the opening minutes after the morning bell.
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