In the opening minutes after the morning bell, the 225-issue Nikkei Stock Average fell 68.60 points, or 0.30 percent, from Tuesday to 22,546.09.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, shed 1.09 points, or 0.07 percent, at 1,570.62.
Real estate, air transportation and mining issues comprised early notable decliners.
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