As of 9:15 a.m., the 225-issue Nikkei Stock Average lost 43.97 points, or 0.19 percent, from Tuesday to 22,840.25.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, shed 0.44 point, or 0.03 percent, at 1,582.30.
Pharmaceutical, precision instrument and land transportation issues comprised those that declined the most in the opening minutes after the morning bell.
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