As of 9:15 a.m., the 225-issue Nikkei Stock Average lost 72.04 points, or 0.36 percent, from Tuesday to 19,795.08.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, added 4.71 points, or 0.33 percent, at 1,411.39.
Rubber product and transportation equipment issues led notable advancers, while pharmaceutical and services issues comprised issues that declined the most in the opening minutes after the morning bell.
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