As of 9:15 a.m., the 225-issue Nikkei Stock Average dropped 122.43 points, or 0.52 percent, from Tuesday to 23,311.30.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 9.44 points, or 0.57 percent, at 1,636.31.
Pharmaceutical, iron and steel, and nonferrous metal issues comprised those that declined the most in the opening minutes after the morning bell.
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