The 225-issue Nikkei Stock Average shed 10.91 points, or 0.05 percent, from Tuesday to close the day at 23,422.82.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, edged up 0.04 points, or 0.72 percent, to finish at 1,646.47.
Pharmaceutical and farm and fishery issues led notable decliners, while marine transportation, and iron and steel issues comprised those that gained the most by the close of play.
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