The 225-issue Nikkei Stock Average dropped 109.10 points, or 0.46 percent, from Wednesday to 23,517.63.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, lost 7.77 points, or 0.47 percent, at 1,636.13.
Pharmaceutical, precision instrument, and farm and fishery-oriented issues comprised those that declined the most by the morning break.
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