As of 9:15 a.m., the 225-issue Nikkei Stock Average lost 160.16 points, or 0.58 percent, from Tuesday to 27,407.99.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, dropped 16.59 points, or 0.91 percent, at 1,802.59.
Iron and steel, textile and apparel and mining-oriented issues comprised those that declined the most in the opening minutes after the morning bell.
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