The 225-issue Nikkei Stock Average lost 132.61 points, or 0.58 percent, from Tuesday to close the day at 22,751.61.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, dropped 9.78 points, or 0.62 percent, to finish at 1,572.96.
Transportation, pharmaceutical and precision instrument issues comprised those that declined the most by the close of play.
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