As of 9:15 a.m., the 225-issue Nikkei Stock Average lost 509.34 points, or 1.78 percent, from Wednesday to 28,125.87.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, fell 31.15 points, or 1.67 percent, at 1,828.92.
Insurance, nonferrous metal and real estate-linked issues comprised those that declined the most in the opening minutes after the morning bell.
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