As of 9:15 a.m., the 225-issue Nikkei Stock Average lost 170.71 points, or 0.56 percent, from Wednesday to 30,462.90.
The broader Topix index of all First Section issues on the Tokyo Stock Exchange, meanwhile, fell 1.01 points, or 0.05 percent, at 1,960.48.
Air transportation, pharmaceutical and land transportation issues comprised those that gained the most in the opening minutes after the morning bell.
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